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Monday, August 6, 2012

Fertility Drugs Seem to Affect Breast Cancer Risk in Younger Women

2012-08-03

A study suggests that women younger than 50 who use fertility drugs to successfully conceive a child may have a higher risk of breast cancer. Still, this higher risk is about the same as the average woman?s risk, but higher than women who took fertility drugs and didn?t conceive.

The study was published online on July 12, 2012 by the Journal of the National Cancer Institute. Read the abstract of ?Fertility Drugs and Young-Onset Breast Cancer: Results From the Two Sister Study.?

Fertility drugs stimulate the ovaries to produce more mature eggs than normal. Without fertility drugs, only one or two eggs, at most, per cycle are released. With fertility drugs, as many as eight to 10 mature eggs can be released. But using fertility drugs greatly increases the amount of estrogen in the body. This extra estrogen may stimulate the growth of hormone-receptor-positive breast cancer cells. Still, results from earlier studies on fertility drugs and breast cancer risk have been mixed, so researchers haven?t been able to make a conclusive connection.

In this study, called the Two Sister Study, the researchers looked to see if there were any associations between using two fertility drugs -- clomiphene citrate (brand name: Clomid) and follicle-stimulating hormone -- and the risk of developing breast cancer in women younger than 50.

The Two Sister Study included 1,422 women who had been diagnosed with breast cancer when they were younger than 50 and their 1,669 sisters who hadn?t been diagnosed.

The women self-reported whether they had ever taken any fertility drugs. If they had, the researchers also wanted to know:

the type
when the women started taking the drug
how long they had taken the drugs
whether the fertility drugs had led to a pregnancy that lasted 10 weeks or longer

The researchers found that women who used fertility drugs to successfully conceive had a higher risk of breast cancer compared to women who used fertility drugs and didn?t conceive. But this higher risk was the same as women who hadn?t used fertility drugs.

The women who used clomiphene citrate alone or both clomiphene citrate and follicle stimulating hormone and didn?t conceive had a lower risk of breast cancer compared to women who didn?t use any fertility drugs.

It?s important to know that while the women who used fertility drugs and didn?t conceive had a lower risk of breast cancer than the average woman, the researchers don?t think that the fertility drugs offered any protection from breast cancer. Instead, it seems likely that women who have trouble conceiving have lower levels of estrogen than average, and so have a lower risk of breast cancer.

It?s also very important to know that women who used fertility drugs and successfully conceived a child didn?t have a higher-than-average risk of breast cancer. Their risk was just higher than it was before they took the fertility drugs and conceived.

Finally, it?s also important to know that conceiving a child without fertility drugs doesn?t increase breast cancer risk.

While this study is large, it does have some limitations. The women had to remember when and for how long they took fertility drugs, so some of the information may have been misreported. We also don?t know what will happen to the women who used fertility drugs as they age. The aging process is the biggest risk factor for breast cancer. That?s because the longer we live, the more opportunities there are for genetic damage in the body. It?s not clear if taking fertility drugs earlier in life will have any effect on breast cancer risk later in life.

The study also focused on younger women diagnosed with breast cancer. In many cases, breast cancer in younger women is linked to two abnormal genes: BRCA1 (BReast CAncer gene one) and BRCA2 (BReast CAncer gene two). Abnormal BRCA1 and BRCA2 genes may account for up to 10% of all breast cancers, or 1 out of every 10 cases. The researchers didn?t take into account whether the women who had been diagnosed had an abnormal breast cancer gene, which would have greatly influenced their risk of breast cancer.

If you?re having trouble conceiving a child and are considering fertility treatments, it?s good to know that this study didn?t show that fertility drugs increased the risk of breast cancer above that of the average woman.

For more information on infertility issues, you may want to visit http://resolve.org/, the website of RESOLVE: The National Infertility Association, an organization devoted to providing education and support to people with fertility problems. RESOLVE is headquartered in McLean, Virginia and has chapters across the country.

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Source: http://www.breastcancer.org/risk/new_research/20120803.jsp

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Murray drubs Federer for gold at Olympics

Britain's Andy Murray celebrates after defeating Switzerland's Roger Federer to win the men's singles gold medal match at the All England Lawn Tennis Club at Wimbledon, in London, at the 2012 Summer Olympics, Sunday, Aug. 5, 2012. (AP Photo/Victor R. Caivano)

Fans of Andy Murray of Great Britain cheer during his match against Roger Federer of Switzerland during the gold medal men's singles at the All England Lawn Tennis Club in Wimbledon, London at the 2012 Summer Olympics, Sunday, Aug. 5, 2012. (AP Photo/Elise Amendola)

Roger Federer of Switzerland wipes his face as he competes with Andy Murray of Great Britain during the gold medal men's singles match at the All England Lawn Tennis Club in Wimbledon, London at the 2012 Summer Olympics, Sunday, Aug. 5, 2012. (AP Photo/Elise Amendola)

Andy Murray of Great Britain watches his return to Roger Federer of Switzerland during the gold medal men's singles match at the All England Lawn Tennis Club in Wimbledon, London at the 2012 Summer Olympics, Sunday, Aug. 5, 2012. (AP Photo/Elise Amendola)

Andy Murray of Great Britain returns to Roger Federer of Switzerland during the gold medal men's singles match at the All England Lawn Tennis Club in Wimbledon, London at the 2012 Summer Olympics, Sunday, Aug. 5, 2012. (AP Photo/Elise Amendola)

WIMBLEDON, England (AP) ? Andy Murray stood with the Union Jack draped over his shoulders, an Olympic gold medal around his neck, flanked by the man he had just beaten, Roger Federer, and basking in the roar of the Centre Court crowd.

No wonder the often dour Scotsman was grinning.

Murray won one for the home team Sunday, beating Federer 6-2, 6-1, 6-4 in the tennis final at Wimbledon.

The victory marked a career breakthrough for Murray. He has lost all four of his Grand Slam finals, three against Federer, including Wimbledon a month ago.

"It has been the best week of my tennis career by a mile," Murray said. "I've had a lot of tough losses. This is the best way to come back from the Wimbledon final. I'll never forget it."

For Federer, the drubbing marked another Olympic disappointment. Playing in the games for the fourth time, he sought a victory to complete a career Golden Slam but settled for silver ? his first singles medal.

"Don't feel too bad for me," Federer said. "I felt like I won my silver, I didn't lose it. So I feel really happy."

Murray swept nine consecutive games to take control, breaking Federer's serve four times in a row, his inspired play a reflection of raucous crowd support. He erased all nine break points he faced.

"He never looked back," Federer said. "His credit for getting in the lead and using the crowd to come through. He did an unbelievable job."

The match capped the most memorable Olympics for tennis since it returned to the games in 1988 after a 64-year absence. The event transformed staid Wimbledon into a more festive place.

Murray became the first British man to win the gold in singles since Josiah Ritchie in 1908. Those games took place at Wimbledon, too.

In the day's first match on Centre Court, women's singles champion Serena Williams teamed with sister Venus to win their third career doubles gold medal. They defeated Andrea Hlavackova and Lucie Hradecka of the Czech Republic 6-4, 6-4 under the retractable roof.

Murray settled for a silver in mixed doubles with teammate Laura Robson. They lost to Victoria Azarenka and Max Mirnyi of Belarus 2-6, 6-3, 1-0 (8).

Mike Bryan won his second medal of the weekend when he and U.S. teammate Lisa Raymond took the bronze in mixed doubles, which was back in the Olympics for the first time since 1924. Bryan and his brother Bob won the gold in men's doubles Saturday.

Maria Kirilenko and Nadia Petrova of Russia took the bronze in women's doubles, while Juan Martin del Potro of Argentina won the bronze in men's singles.

Rafael Nadal, the 2008 gold medalist in singles, tweeted his congratulations to this year's medalists.

"Especially to Andy," said Nadal, sidelined with a recurring knee injury. "I can imagine the joy of doing it at home."

Murray had the crowd's support even playing against the beloved Federer. The roof opened shortly before the match, and Federer ? winner of seven Wimbledon titles ? walked onto the sun-splashed grass to a standing ovation.

Then Murray entered, and an ovation became a roar.

At the far end of the All England Club, thousands of fans with grounds passes enjoyed a carnival atmosphere on the picnic hill known as Murray Mount while watching the match on a huge video screen.

Federer wore red and Murray blue in the most colorful tournament ever held at Wimbledon. Their tactics were also in sharp contrast.

Murray returned aggressively to repeatedly put Federer on the defensive when serving. Federer tried to come forward more than in any match this summer, but Murray answered with a succession of crisp passing shots for winners.

"Andy looked like he was never doubting himself," Federer said. "He had a clear plan."

The fans loved it, waving British flags of all sizes. "An-dy! An-dy" they chanted. They applauded when Federer won a point, but they boomed when Murray won one.

And the bounces seemed to go Murray's way. One of his service breaks came when he hit winners that clipped the net cord on successive points. But then the net, after all, was British.

Altogether Federer dropped serve five times, surprising anywhere but especially on grass. He also lost 15 of 33 points when he went to the net, often watching groundstrokes by Murray whiz past out of reach.

"That's the best part of his game," Federer said. "If he doesn't do those passing shots, he's not going to win gold."

The impassive Swiss showed little frustration as the match slipped away. Instead, it was Murray tossing his racket in the second set when he made a rare error.

Otherwise, Murray had little to get upset about. When he netted an easy forehand on break point early in the match, he laughed at his mistake.

"I felt so fresh," he said. "I didn't feel nervous really at all, apart from at the beginning of the match."

He won with plenty of flair and a succession of spectacular shots. A lunging backhand pass in the corner had fans on their feet. And he erased a break point with an acrobatic leaping overhead, followed by an improbable reflex volley winner after Federer fired at him from point-blank range.

Murray fell behind 15-40 serving in the opening game but rallied to hold, and from 2-all he took charge, winning every game until 5-0 in the second set.

Federer struggled to hold but had many chances to break, including in the third game of the second set, a marathon that lasted for 20 points. He held six break points but Murray erased them all and won the game on an errant Federer backhand, one of many.

"If those points had gone a different way, it could have been a different match," Murray said.

Federer, taxed by his 19-17 third-set semifinal win Friday, couldn't summon a comeback. Murray hurried to the finish line, winning 20 of 21 points on his serve in the final set.

He reached match point with an ace, then hit another at 131 mph to seal the win. He briefly sank toward the turf, then rose to share a warm embrace with a smiling Federer.

"I was very happy for him," Federer said. "It's a long time coming for him, and he did great."

Murray climbed into the player box to share hugs with friends and family. He then leaped back onto the court, and when he threw a final knockout punch, the crowd roared one more time.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-08-05-OLY-TEN-Wimbledon/id-9396526f3961413cae19e707da404f78

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After 1 week, Colts' new QB still has work to do

By MICHAEL MAROT

AP Sports Writer

Associated Press Sports

updated 11:19 a.m. ET Aug. 5, 2012

ANDERSON, Ind. (AP) - Andrew Luck keeps getting rave reviews from longtime NFL players and coaches.

He's not sure he deserves them.

The No. 1 overall draft pick says he's still trying to learn the Colts offense, get in sync with his new receivers and figure out how to read NFL defenses.

Unofficially, Luck completed 122 of 162 passes with seven touchdowns and five interceptions in team drills during the first week of training camp. Yet the numbers that jump out to the Stanford grad are the interceptions.

Luck has often been hyped as the most NFL-ready quarterback since Peyton Manning entered the league in 1998, also with the Colts.

But the two-time Heisman Trophy runner-up still thinks there's a lot to learn - and prove - before he can join the same category.

More news

Reid's son found dead

Garrett Reid, the oldest of Eagles head coach Andy Reid?s three sons, was found dead in his dorm room at the team?s training camp headquarters at Lehigh University Sunday morning, General Manager Howie Roseman told reporters after the team?s walk-through.

Source: http://nbcsports.msnbc.com/id/48515262/ns/sports-nfl/

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General says all Damascus retaken, Aleppo pounded

The Syrian army said on Saturday it has seized the last rebel-held district of the capital as insurgents in the strategic northern city of Aleppo came under heavy bombardment by regime forces.

The army said it had retaken the hold-out rebel district of Tadamun in Damascus, a day after the United Nations deplored the failure of diplomacy to end a conflict that has reportedly claimed more than 21,000 lives in nearly 17 months.

A brigadier general who refused to give his name told journalists visiting the neighbourhood of Tadamun, the scene of heavy fighting earlier, that it has been retaken, and that the military now controls all of the capital.

"We have cleansed all the districts of Damascus, from Al-Midan to Mazzeh, from Al-Hajar Al-Aswad to Qadam... to Tadamun," the last rebel bastion in the capital, said the officer.

An anti-regime activist, Lena al-Shami, told AFP in Beirut by Skype that the rebel Free Syrian Army (FSA) had withdrawn from Tadaman and would focus on "hit-and-run tactics against important regime targets."

Tadamun borders the Palestinian refugee camp of Yarmuk and is home to both Syrians and Palestinians. It is now deserted and devastated, with electricity cables hanging down between rooftops and paving badly damaged.

In Yalda next to Tadamun, an AFP reporter saw a dozen corpses thrown on a rubbish dump. Some had been burned and others mutilated.

Fighting erupted in Damascus on July 15 and raged for several days as rebels seized several districts, forcing thousands of residents to flee.

In Aleppo, Abdel Jabar Oqaida, commander of the FSA there, said the Salaheddin district had "come under the heaviest bombardment since the battle began" on July 20 but that loyalists had "not managed to advance."

A senior government security figure warned that "the battle for Aleppo has not yet begun, and what is happening now is just the appetizer... The main course will come later."

The official said more reinforcements had arrived and that at least 20,000 troops were now on the ground. "The other side are also sending reinforcements," the official added of the rebels, who claim to have seized half the city.

Because of restrictions on the free movement of journalists in Syria, none of the claims can be verified.

Echoing UN chief Ban Ki-moon's remarks on Thursday that violence was intensifying, a watchdog said July was the deadliest month since the uprising against President Bashar al-Assad's regime erupted in March 2011.

Rami Abdel Rahman who heads the Syrian Observatory for Human Rights said 4,239 people, the vast majority civilians, died last month, bringing the overall toll since March 2011 to more than 21,000.

Explosions shook Aleppo as fighter jets and helicopter gunships overflew the city and rebels tried to storm the state television building before being driven back by shelling, said the Britain-based Observatory.

State media said the army defended the site from "mercenary terrorist groups."

The violence killed at least 78 people across Syria on Saturday, including at least eight in Aleppo province, the Observatory said, listing the dead as 45 civilians, 26 regime forces and seven rebels.

On Friday, a day after UN and Arab League envoy Kofi Annan resigned in frustration over the failure of an April peace plan to take hold, Ban warned world powers they must overcome their rivalries to put an end to a "proxy war" in Syria.

And the UN General Assembly voted overwhelmingly to condemn the Security Council for its failure to act and condemned the Syrian regime for using heavy weapons.

Ban said growing radicalisation and extremism had been predicted at the start of the uprising, as had been a "proxy war, with regional and international players arming one side or the other."

After the General Assembly vote, US Ambassador Susan Rice said that "despite the continued opposition of an increasingly isolated minority, the overwhelming majority of UN members clearly stands resolutely with the Syrian people."

That was an allusion to Russia and China, who voted against the resolution and who had already vetoed three Security Council resolutions on Syria.

But Russian Ambassador Vitaly Churkin said the assembly gave "blatant" support to Syrian rebels and that its backers were the countries providing "mercenaries and arms" to the opposition.

China's deputy ambassador, Wang Min, said pressuring only Damascus would "cause further escalation of the turmoil and let the crisis spill over to other countries in the region."

On Saturday, senior foreign ministry official Wang Kejian accused countries that oppose its position of pursuing their own geopolitical interests and "trying to hinder or even undermine the political settlement process."

France's UN ambassador, Gerard Araud, said Paris would use its presidency of the Security Council to push for humanitarian aid for Syrians, warning Russian and Chinese intransigence could lead to "a final disaster."

While political progress "will be difficult," he said things can be done "on the humanitarian front because, above and beyond the deadlock on the Security Council or the resignation of Annan, there is the suffering of the Syrians."

In other developments on Saturday, Qatar said Arab states will not accept a replacement for Annan unless the nominee's mandate is to clearly negotiate a transfer of power in Syria.

And 48 Iranian pilgrims were kidnapped in Damascus, Tehran's consul said, while an official in Ankara said another Syrian general had defected to Turkey.

Source: http://news.yahoo.com/un-chief-scolds-world-powers-syria-fighting-rages-034644858.html

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Democrats launch national effort to help Dream Act kids stay legally ...

Democrats in both chambers have launched a national effort to enroll young illegal immigrants in a new program letting them stay in the country without threat of deportation.

With the Obama administration's "deferred action" program set to take effect Aug. 15, the Democrats are organizing outreach programs nationwide to help potential beneficiaries navigate applications, understand fees and avoid expensive scams.

"We suspect that most of the 1 million eligible [people] will not need a lawyer," Rep. Luis Gutierrez (D-Ill.), Congress's most vocal immigrant-rights advocate, said Thursday during a press briefing at the Capitol. "If you see a lawyer, and they're calling you, and they're offering you something and they're asking you to write a check, run away!"

On Friday, the Department of Homeland Security (DHS) issued a series of guidelines that will govern the application process, including specifics about the fee ($465) and eligibility requirements.

In Chicago, Gutierrez will join Mayor Rahm Emanuel (D) and Sen. Dick Durbin (D-Ill.) in hosting a workshop to get potential beneficiaries enrolled. At least 17 other cities, including Detroit and Los Angeles, are staging similar events.

Rep. Howard Berman (D-Calif.), the sponsor of the original Dream Act, said the outreach efforts are largely intended to beat back myths surrounding the soon-to-launch program, including the notion that rejected applicants will be marked for deportation.

"I think we can safely say [that] no one will be retaliated against because they submitted an application for which it turned out they didn't meet the requirements," Berman said.?

The lawmakers are almost pleading with young illegal immigrants to take advantage of the help.

"We don't want you to be so desperate to cross that bridge [into the program] that you cross it with the wrong individuals," said Rep. Yvette Clarke (D-N.Y.). "They are out there ready to profit from your anxiety."?

Unveiled in June by the DHS, Obama's deferred action program will allow qualified illegal immigrants who were brought to the United States as children to remain here ? a concept modeled on the Dream Act legislation that has been unable to pass Congress.

The two-year program does not create a route to citizenship ? like versions of the DREAM Act do ? but it would empower high-achieving illegal immigrants to work or study without fear of deportation.

To be eligible, applicants must have come to the United States before the age of 16; lived in the country continuously for at least the last five years; obtained a high school degree, a GED or still be in school; and possess a clean criminal record.

"If you have criminal involvement, you're out," Gutierrez said.

Republicans have hammered Obama for the unilateral move, saying it was an unconstitutional power-grab that ignores the will of Congress.?

Rep. Lamar Smith (R-Texas), chairman of the House Judiciary Committee and one of Obama's loudest critics on immigration policy, said Friday that the program "undermines the rule of law and gives lawbreakers an unfair advantage over legal immigrants."

"In order to process the millions of applications from illegal immigrants, the Obama administration will have to divert funding and other resources from processing legal immigration applications," Smith said in a statement responding to the new DHS guidelines. "This will lead to a backlog for legal immigrants who followed the rules, while allowing lawbreakers to skip to the front of the line."?

Obama has fired back, arguing that the changes were necessary to protect talented kids from a Congress that wouldn't.

"It makes no sense to expel talented young people who, for all intents and purposes, are Americans," Obama said in announcing the program. "They have been raised as Americans [and] understand themselves to be part of this country."

There was also a political significance to Obama's decision, as the immigration debate has put Mitt Romney, the GOP's presumptive presidential nominee, in a tough spot. The former Massachusetts governor had tacked hard to the right against illegal immigrants during the hotly contested GOP primary ? a move designed to appease conservatives who consider anything but deportation to be amnesty ? but he's since softened that position in an effort to appeal to the country's growing bloc of Hispanic voters.

Capitol Hill Democrats are approaching the program's launch cautiously, seemingly aware that its success ? both political and practical ? hinges first on participation.

"It's an exciting situation," Berman said, "but if people don't know about it ? if people don't know how to do it ? it's a hollow kind-of a promise."?

DHS is not accepting applications for the deferred action program before Aug. 15.

Source: http://thehill.com/homenews/house/242241-democrats-launch-national-effort-to-help-dream-act-kids-stay-legally-in-us-

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Sunday, July 15, 2012

UN investigates Syria massacre site

By msnbc.com news services

Updated at 630 p.m. ET: United Nations observers found blood, burned homes and signs of artillery fire in the Syrian village of Tremseh on Saturday but were unable to confirm activists' reports that about 220 people were massacred in an attack that prompted international outrage.

The investigation came along with two other key developments in the reported mass slaying by regime forces, who activists say have killed more than 17,000 people since the uprising against killings by President Bashar Assad?s rule began in March 2011:

Turkey's prime minister blasted Damascus' leadership, warning that the Syrian people will "make them pay" for such mass killings.
The International Committee of the Red Cross now views fighting in Syria as an internal armed conflict ? a civil war in layman's terms ? crossing a threshold experts say can help lay the ground for future prosecutions for war crimes.

On Saturday, an 11-vehicle team of observers went into the central village of Tremseh after receiving confirmation a cease-fire was in place,?said spokesman for the U.N. mission in Syria Ahmad Fawzi. It was the first outside look into the village where activists say at least 150 people were killed by government troops who shelled the town before moving in alongside pro-regime militiamen.

Anonymous / AP

This image made from amateur video from Hama Revolution 2011 and accessed by AP video, purports to show a funeral for victims killed by violence that, according to anti-regime activists, was carried out by government forces in Tremseh, Syria, on Thursday.

"We have sent a large integrated patrol today to seek verification of the facts," Fawzi said.

Details of the killings remain unclear. The Syrian government says 50 people were killed in Tremseh Thursday when its forces clashed with "armed gangs" terrorizing village residents. The regime refers to its opponents as terrorists and gangsters. On Friday, the United Nations blamed government forces for the Tremseh assault, saying U.N. observers deployed near the village saw government troops using heavy weaponry and attack helicopters against it.

US source: Syria is moving its chemical weapons

"The attack on Tremseh appeared targeted at specific groups and houses, mainly of army defectors and activists," the spokesman for the U.N. observer mission to Syria said later?in an emailed statement.

"A wide range of weapons were used, including artillery, mortars and small arms."

Opposition activists say government forces killed about 220 people in the village. U.N. observers said they had found a burned school and fire-damaged houses.

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World leaders have heaped criticism on Assad's regime over the Tremseh incident.

A suicide bomber blew up his car in the closest main town to Tremseh on Saturday, killing three civilians and one security officer, Syria's state news agency said.

SANA said the attacker, who camouflaged the bomb with onions, detonated the explosives in the town of Muhrada.

Warning from Turkey
The prime minister of Turkey ? once an ally of Assad before turning against him early on in the uprising over the regime's bloody crackdown, blasted Syria's leadership on Saturday over the Tremseh killings.

"These vicious massacres, these attempts at genocide, these inhuman savageries are nothing but the footsteps of a regime that is on its way out," Recep Tayyip Erdogan said. "Sooner or later, these tyrants with blood on their hands will go and the people of Syria will in the end make them pay."

Donatella Rovera of Amnesty International discusses reports of bloodshed on a major scale in the central part of Syria.

Red Cross declaration
The Red Cross, guardian of the Geneva Conventions setting down the rules of war, previously classed the violence in Syria as localized civil wars between government forces and armed opposition groups in three flashpoints ? Homs, Hama and Idlib. But hostilities have spread to other areas, leading the Swiss-based agency to conclude the fighting meets its threshold for an internal armed conflict and to inform the warring parties of its analysis and their obligations under law.

"There is a non-international armed conflict in Syria. Not every place is affected, but it is not only limited to those three areas, it has spread to several other areas," ICRC spokesman Hicham Hassan told Reuters in response to a query.

"That does not mean that all areas throughout the country are affected by hostilities," he said.

The qualification means that people who order or commit attacks on civilians including murder, torture and rape, or use disproportionate force against civilian areas, can be charged with war crimes in violation of international humanitarian law.

This article includes reporting by Reuters and The Associated Press.

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Source: http://worldnews.msnbc.msn.com/_news/2012/07/14/12741921-un-team-investigates-massacre-in-syria-village?lite

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